Kongenitale Ichthyose - Deutsche Dogge Searchterm for breeding approval or club

for breeding approval or club registration)

Genetic defect impairs protein physiological function in the eye

Mutation: C3 gene

No obvious ocular or auditory involvement and secondary joint problems were detected in affected dogs like in some other diseases with short-legged phenotype

bs or be are detected

Kongenitale Ichthyose - Deutsche Dogge Searchterm for breeding approval or clubHereditary ichthyoses represent a heterogeneous group of skin cornification disorders characterized by hyperkeratosis and blistering or scaling of different severity levels. In Great Dane the disease is characterized by severe hyperkeratosis with a formation of strongly wrinkled, thickening and scaling skin, especially in the region of eyes and nose. The symptoms become evident right after birth and thus include dry and scaling skin, untidy appearance