Kongenitale Methämoglobinämie Labrador Retriever Mutation: COL11A1-Gen

Mutation: COL11A1-Gen

The age of onset of the multifocal retinopathy ranges from 9 months to 2 years

this approach carries the risk of overusing certain sires

Non-ocular manifestation of the disease includes stunted growth

Betroffene Hunde verlieren aufgrund von Muskelatrophie an Gewicht

Kongenitale Methämoglobinämie Labrador Retriever Mutation: COL11A1-GenMethaemoglobinaemia is an autosomal recessive disorder of NADH cytochrome B5 reductase deficiency. It is characterized by a defect of cytochrome B5 reductase pathway causing oxidation of haemoglobin to methaemoglobin, which overwhelms the reductive capacity of this pathway, crucial for maintaining methaemoglobin concentrations at < 2 % of total haemoglobin. The clinical signs include decreased energy or exertional syncope, which are consequences of