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Mutation: SLC7A9 gene
The first signs of disease may be apparent as early as 4 weeks to 6 month of age
dragging of paws and loss of conscious proprioception
Die Kombination von zwei rezessiven Allelen führt zu schokoladen-/leberbrauner Farbe (zum Beispiel zwei bc-Allele oder ein bc- und ein bs-Allele)
The enzyme succinic semialdehyde dehydrogenase has important role in part of the metabolism of the neurotransmitter GABA
Progressive Retinaatrophie (PRA-CNGA1) option-set-443684-checkbox-1 Mutation: SLC7A9 geneProgressive retinal atrophy (PRA) is an inherited disease that occurs in many breeds of dogs and is reflected in various clinically indistinguishable forms. Progressive rod and cone degeneration in retina leads to progressive vision loss, which can end with total blindness. A form of PRA called CNGA1 PRA was described in Shetland sheepdog. On average clinical signs become apparent at 5 years of age (2 11 years). The breed suffers from an additional
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