Polyneuropathie 2 (LPN2) - Leonberger evg-analysen Mutations in this gene can

Mutations in this gene can lead to impaired hunger regulation and obesity

When breeding with a Merle carrier

wobei alle betroffenen Hunde die Krankheit bis zum Alter von 6 Jahren entwickeln

das für die Aktivierung des Faktors X in der Blutgerinnungskaskade erforderlich ist

Mm = merle

Polyneuropathie 2 (LPN2) - Leonberger evg-analysen Mutations in this gene canPolyneuropathy (PN) is a progressive neurological disease with typically signs like hypotonia, muscle atrophy secondary to denervation and abnormal motor signs. Early signs are laryngeal paralysis, inspiratory stridor and dyspnoea and are considered as strong indicator of neuropathy that may later progress. Clinical signs in Leonberger vary greatly and have different age of onset from <1 year to 10 years of age. A mutation in GJA9 gene was identified