Bernard-Soulier-Syndrom (BSS) Katzen Italian Greyhound

Italian Greyhound

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The mutations in the gene that codes factor IX result in the insufficient or absent levels of factor IX in the blood

Mutation: NHEJ1 gene

Transparent and traceable breeding decisions

Bernard-Soulier-Syndrom (BSS) Katzen Italian GreyhoundBernard Soulier syndrome (BSS) is a rare bleeding disorder affecting platelet function found in humans and dogs (Cocker Spaniel). The main molecular feature of BSS is the lack of functional glycoprotein Ib IX V on the platelet surface responsible for weakened binding to von Willebrand factor and reduced ability to adhere to damaged vascular walls. In affected dogs macrothrombocytopenia is present with almost half of the platelets approximating the red