Neuronale Zeroidlipofuszinose 8 (NCL-8) - Alpenländische Dachsbracke Diversität Affected dogs have abnormal platelet

Affected dogs have abnormal platelet function because they are not able to stick together properly and therefore cannot form a clot

The symptoms are only present in bright light

which can occur episodically

This waste material affects nerve cell function

The dog carries one copy of 'cocoa' alelle and one copy of 'N' alelle

Neuronale Zeroidlipofuszinose 8 (NCL-8) - Alpenländische Dachsbracke Diversität Affected dogs have abnormal plateletNeuronal ceroid lipofuscinoses (NCLs) are a group of heritable diseases characterized by progressive neuronal degeneration and the accumulation of autofluorescent cytoplasmic inclusions in the brain, retina and other tissues. Clinical symptoms and progress of the disease include increased rates of irritability, with the possibility of outbursts of aggression, hallucinations, hyperactivity and seizures. Most animals lose their ability to coordinate