Zentronukleäre Myopathie (IMGD) - Deutsche Dogge Mischling life-threatening disorder of weak and

life-threatening disorder of weak and thin heart

Episodes occur more commonly in temperamental animals that are more excited under stress

tan or pink subretinal fluid in the eye

ein rezessives Allel kann an die Nachkommen weitergegeben werden

The affected puppies often have to be euthanised due to severe symptoms and the risk of a sudden death

Zentronukleäre Myopathie (IMGD) - Deutsche Dogge Mischling life-threatening disorder of weak andCharacteristic signs of centronuclear myopathies include generalized muscle weakness, atrophy, predominance of type I fibres, and aberrant cell positioning of nuclei and mitochondria. In Great Danes generalized muscle atrophy, exercise intolerance, exercise induced tremor and muscle wasting characterize the disease. The disease typically starts before 10 months of age, is highly progressive, and most of the affected dogs are euthanized before 18