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Ideally, an effective combination drug therapy for treating obesity would enhance the magnitude and temporal duration of weight loss but would also engage a set of partially-overlapping, complementary neural circuits to mechanistically suppress feeding
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1998 (Eur J Endocrinol) established selectivity vs
However, these risks may be due to the presence of obesity, long-term diabetes, and the use of other drugs
doi: 10.1177/1060028020935105 127 LinSDengYHuangJLiMSoorannaSRQinMet al
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