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(B) Intraperitoneal glucose tolerance test (IPGTT) with 15% D-glucose

Therefore, modeling approaches can be valuable for examining the extent of pharmacokinetic DDIs driven by these mechanisms

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In the context of retatrutide, the glucagon signal appears to promote fatty acid oxidation in the liver and increase resting energy expenditure, effects that complement the caloric intake reductions driven by GLP-1 and GIP signalling