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While transdermal patch technology has advanced, injectable GLP-1 agonists remain the clinical gold standard because they achieve therapeutic blood levels that patches cannot consistently match
Their effects are marked by increased satiety, reduced appetite, and improved metabolic biomarkers, with a safety profile dominated by mild to moderate gastrointestinal adverse events
And the neurological effects of sustained amylin receptor activation in brain regions governing energy homeostasis may contribute directly to feelings of tiredness
doi: 10.1146/annurev-nutr-110420-111710 138
Studies in women with PCOS show that GLP-1 therapy produces weight losses of 510% over 612 months, with concurrent improvements in menstrual regularity, fertility markers, and cardiovascular risk factors
