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IGF-1 acting through the IGF-1 receptor and downstream PI3KAktmTOR and MAPK signalling cascades mediates the principal anabolic, growth-promoting, and tissue-remodelling effects of the GH/IGF-1 axis

Failure to identify B12 deficiency can lead to a faulty diagnosis and expensive treatments for the wrong condition

Although there is a relationship between low vitamin B 12 levels and cognitive decline, clinical studies - including those involving people with Alzheimer's disease - have not shown improvement in cognitive function, even doses of vitamin B 12 as high as 1000 micrograms per day