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Tara Scott, an OB-GYN menopause specialist, explains the biology: the brain cannot distinguish physical from psychological stress, and as progesterone falls, the HPA axis loses a major buffer

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N Engl J Med 384(11):9891002 Frias JP et al (2021) Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes

He says, "Heres this drug thats central to liver, kidneys, brain, pancreas, muscle tissue, and so, yeah, its a powerful drug thats complicated that requires a clinician who is trained to use it to prescribe. Dr