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Diagnosis is made by exclusion of alcohol abuse and other causes of liver disease (HBV-related hepatitis, HCV-related hepatitis, autoimmune liver diseases, polycystic ovary syndrome, drug-induced liver disease and congenital causes such as hereditary hemochromatosis, Wilsons disease, alpha-1 antitrypsin deficit)
Hamley IW et al
This mitochondrial enzyme has been studied extensively as a protective factor in metabolic cardiomyopathy, in the setting of which it has been shown to normalize contractile function
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