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On 24 November 2025, Novo Nordisk reported that oral semaglutide had failed to slow Alzheimers disease in the EVOKE and EVOKE+ trials, which together enrolled 3,808 participants and stand as the largest evaluation of this drug class in any neurodegenerative condition [1]

I am no longer on medication, and am maintaining my weight! Aside from the Ozempic face change, another alarming side effect from the weight loss drug is Ozempic teeth. Those who use the GLP 1 might have experienced dental issues such as dry mouth, bad breath and gum disease

~7% for tirzepatide in SURMOUNT-1) and a new dysesthesia signal at ~21% incidence that didn't appear in Phase 2

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