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Many literatures proved that GLP-1 derivatives performed neuroprotective effects and inhibited neuronal apoptosis ( Figure 1 There are also a type of non-peptide small molecules, which are mainly extracted from herbal medicine, such as Cornus officinalis , Gardenia jasminoides , Rehmannia glutinosa , Lamiophlomis rotata , and Strychnos nuzi ( Even for patients without complications of diabetes, their cognitive functions were still significantly improved ( 3 The neuroprotection of GLP-1RA in experimental stroke Many literatures indicated that GLP-1RA were also considered as the latent intervention strategy against ischemic stroke to improve the pathological symptoms and prognosis