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Obesity may worsen T1D by increasing insulin resistance and the required insulin doses, leading to a vicious cycle of weight gain and elevated insulin needs
After reaching maintenance doses and completing the adaptation period, most participants experience significant reduction in side effect frequency and severity
How This Works Semaglutide is a GLP-1 receptor agonist : it selectively engages the GLP-1 (glucagon-like peptide-1) receptor, the pathway that helps regulate appetite, satiety and glucose-dependent insulin release [1] [5]
We present this article in accordance with the Narrative Review reporting checklist (available at Methods A search of the literature was conducted on OVID (1947May 2025) using the terms [papilledema OR intracranial hypertension OR idiopathic intracranial hypertension OR brain pseudotumor] AND [glucagon like peptide 1 OR glucagon like peptide 1 receptor agonist OR semaglutide OR exendin 4 OR liraglutide OR tirzepatide]
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