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Phase 1: loading (weeks 1 to 8) The loading phase establishes tissue levels and initiates regenerative processes

Cellular repair networks linking oxidative defense, collagen synthesis, and immune modulation

In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]