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The remaining DEPs were mainly located in cytoplasmic (22.73% in Sema/HFD, 25.96% in total), extracellular (16.29% in Sema/HFD, 11.47% in total), plasma membrane (15.15% in Sema/HFD, 11.47% in total) and mitochondrial (9.22% in Sema/HFD, 10.5% in total
Data from other groups and our recent study have shown that endothelium and cardiac and vascular myocytes express a functional GLP-1R, and participate in the protective cardiovascular effects of GLP-1 analogues 11,36,37,38
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It reduces the oxidative stress and production of melanin
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