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GLP-1R predominantly signals through the G/cAMP pathway [7]
The key difference is that Wegovy works by targeting a single hormone receptor (GLP-1), while Mounjaro targets both GLP-1 and another hormone receptor called GIP, which may enhance its effects
This article did not perform independent chemical testing to confirm their absence beyond what the label discloses
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The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%
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