glp-1 receptor agonist use and risk of suicide death agonists or suicide attempts – A nationwide cohort and self-controlled case series study Does GLP-1 Cause Suicidal Ideation?

Gastrointestinal side effects are a little more common in the oral version than in the injectables

doi: 10.1056/NEJMoa1607141 12 HernandezAFGreenJBJanmohamedSD'AgostinoRBSrGrangerCBJonesNPet al

Key Products: Trevogrumab, anti-myostatin antibody designed to preserve lean muscle mass that was tested in combination with semaglutide to offset GLP-1-associated muscle loss

And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat

Single-strand breaks may be repaired by the oocyte after fertilization, but double-strand breaks are more difficult to repair and are often associated with severe chromosomal damage