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In the 1990s, researchers discovered that Gila monster saliva contains a peptide called exendin-4, which acts like GLP-1 but resists enzymatic breakdown

Since the brain runs primarily on glucose, this creates an energy crisis that manifests as cognitive sluggishness, fatigue, and mood disturbance

Strength training Maintaining resistance training is critical to keeping muscle mass during weight loss

GLP-1 pills slow digestion, reduce appetite and food cravings, lower blood sugar, and may promote weight loss

However, the medication quickly became popular for its ability to help people reach their weight loss goals, especially when used under the guidance of a licensed provider