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But the Centers for Medicare & Medicaid Services (CMS) has the authority to test coverage changes through Center for Medicare and Medicaid Innovation (CMMI) models and other statutory demonstration authorities
One trial last year found that Alzheimers patients treated with liraglutide (a similar drug) had a reduction in cell shrinkage and less cognitive decline than those not on the medication
Data regarding prior use of GLP-1RAs or other weight management pharmacotherapies were not collected
Diabetes 56:17831791 Krauss S, Zhang CY, Scorrano L et al (2003) Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
They showed better effects in improving mouse motor function scores, promoting the repair and regeneration of synapses or dopaminergic neurons (TH+, GDNF, synaptophysin), and inhibiting neuroinflammatory responses (IBA-1, IL-2) compared to liraglutide and DA-JC1, highlighting the advantage of targeting more sites
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