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breastfed infants ( The Caco-2 monolayer ( in vitro intestinal model, but it lacks a mucus layer and its tight junctions resemble those of the colon, with narrower pores (4.5 ) ( Previous studies have examined methods for increasing the permeability of Caco-2 monolayers whilst preventing inflammation

In cases with borderline low serum cobalamin levels, measuring serum methylmalonic acid (MMA) and fasting homocysteine levels may clarify whether these are truly low-normal values or whether they instead indicate a physiologically significant functional vitamin B12 deficiency

Extended continuous use can reduce receptor sensitivity and potentially cause copper accumulation concerns

Dutta D et al

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