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Studies in rat models of varicocele have shown markedly decreased intratesticular testosterone concentrations, along with significant functional impairment of 17-hydroxylase and C17,20-lyase, leading to the hypothesis that elevated scrotal temperature directly suppresses the activity of these enzymes (93)

In vitro , in comparison with control, healthy animals, the assessment of splenic cells (day 21) demonstrated that the 6-methylprednisolone animals had declined reactivity to nitrogen, while the addition of BPC 157 (1 g/g cream) returned cell reactivity to normal values (Mikus et al., 2001

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