A role of oxidative stress in GO is supported by a number of basic studies suggesting that ROS promote the proliferation of OFs and the release of GAGs, the synthesis and secretion of cytokines, and the expression of other factors involved in the pathogenesis of GO, namely heat shock protein 72 (HSP-72), HLA-DR and ICAM-1 ( Figure 1 In this context, a number of studies, performed both in vitro and in vivo , investigated the effects of antioxidant agents in GO, including selenium, pentoxifylline, quercetin, enalapril, vitamin C, N-acetyl-L-cysteine and melatonin ( Oxidative Stress and Proliferation of Orbital Fibroblasts Burch et al
The study was supported by the National Institutes of Health, the American Heart Association, the American Diabetes Association and the Juvenile Diabetes Research Foundation
Neither compound affects FSH, LH, PRL, or TSH, providing genuine selectivity for the GH axis
USA 101 , 1265812663 (2004)
Given that, it makes sense that GLP-1 drugs might help