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doi: 10.2337/diacare.28.11.2745 164 CrespoCJSmitESnellingASemposCTAndersenRE

The extrinsic pathway is mediated by binding of death-inducing ligands such as TNF and Fas ligand that bind to cognate receptors that, in turn, recruit adaptor proteins and pro-caspases, leading to the assembly of the death-inducing signaling complex (DISC) and the activation of effector caspases 75

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Among peptides studied in research contexts, BPC-157 carries a notable biochemical characteristic: documented stability in acidic pH (2-3) for over 24 hours, atypical for bioactive peptides