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In these cardiovascular safety trials, in secondary or exploratory analyses, GLP-1 receptor agonists were also shown to reduce macro-albuminuria, an accepted surrogate marker for diabetic kidney disease (DKD), a condition that still represents a major unmet medical need

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Why Dose Increases Matter for GLP-1s When it comes to GLP-1 dose titration, semaglutide and tirzepatide are gradually ramped up for two distinct reasons: To give your body time to adapt to any side effects