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Reduced kidney function, irregular meal patterns, and polypharmacy all increase the danger

Neurokinin 3 Receptor Antagonists Compared With Serotonin Norepinephrine Reuptake Inhibitors for Non-Hormonal Treatment of Menopausal Hot Flushes: A Systematic Qualitative Review

Common modifications include staying at a dose for 8 weeks instead of 4, adding intermediate steps like 0.375 mg or 0.75 mg, or dropping back a tier if gastrointestinal side effects become severe

Side effects include some swelling, redness and tenderness in the treated area