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Lower body mass, different hepatic clearance, and higher GI sensitivity mean women typically respond at lower per-week totals and tolerate slower titration better

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This mechanism creates satiety , but it also means that big portions can feel heavy for hours

Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)