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For purification, a 5 ml StrepTrap HP (GE Healthcare) was equilibrated with at least five column volumes of lysis buffer

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Our portfolio of product candidates is summarized in the figure below: Our lead product candidate, azelaprag: an orally available, small molecule APJ agonist that has the potential to recapitulate the effects of exercise Leveraging our platform, we found that apelin levels decrease with age and that higher levels of apelin are predictive of both improved physical function and increased longevity