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Additional caution may be appropriate in research involving: Additional Monitoring May Be Considered In Research Models Involving: Pregnancy and lactation-related research contexts, where limited safety data is available Severe gastrointestinal or delayed gastric-emptying research models, where GLP-1related pathways may influence gastrointestinal motility-related observations Pancreatic or pancreatitis-related research models, where metabolic and digestive-signaling pathways may require additional monitoring Gallbladder or biliary-related research models, where gastrointestinal and metabolic pathway modulation may influence biliary-related observations Diabetes or glucose-regulation research models involving concurrent glucose-lowering compounds, where glucose-homeostasis pathways may require closer monitoring Severe hepatic or renal impairment research models, where metabolic clearance and tolerability observations may differ Thyroid-related research models, including investigations involving endocrine-signaling pathways, thyroid-related biomarkers, or thyroid-cancer history models Additional Research Considerations Research conditions, protocol structure, research amount, and concurrent compounds may influence tolerability observations across experimental settings

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Edited by Benzie IFF, Wachtel-Galor S