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3,4,5,6 BMP, together with WNT signaling, downregulates OTX2 and upregulates germline-specific factors to segregate germ cells from somatic cells (SCs)
It binds to specific receptors on these cells, triggering a chain of intracellular signaling events
However, in mouse models, administration of Parabacteroides distasonis accelerated progression of diabetes, primarily due to aberrant immune cross-reactivity and reduced Foxp3 + CD4 + Treg cells
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