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Individuals with a BMI of 3034.9 kg/m (or 27.532.4 kg/m for the specified ethnic groups) may be considered if they have at least one weight-related comorbidity

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Roughly twice as many participants stopped orforglipron because of adverse events, mostly gastrointestinal

This is the study regulators will review before granting a broad cardiovascular label, and the one that will ultimately answer the long-term safety question

Semaglutide may not be suitable if you have a family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2, or if youve experienced pancreatitis or severe gastrointestinal issues, alternatives should be discussed with your provider