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Genetic predisposition First-degree relatives have a higher likelihood of developing IC/PBS compared to the general population, indicating that the occurrence of the disease may have a zygotic link, whether monozygotic (identical twins) or dizygotic (fraternal twins) (Warren et al., 2004)

Endoplasmic reticulum (ER) stress Refers to various stresses that lead to protein misfolding and activate the unfolded protein response (UPR)

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