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In November and December 2025, the two largest clinical trials ever run with a glucagon-like peptide-1 receptor (GLP-1R) agonist in a neurodegenerative disease reported their results

BHMT = betaine-Hcy S-methyltransferase

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About the prescription of exenatide and liraglutide, both compounds are contraindicated in MTC patients or multiple endocrine neoplasia syndrome 2 (MEN 2) patients due to the increased incidence of C-cell hyperplasia and tumors combined with elevated calcitonin levels in preclinical studies in rodents