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In fact, LR3 IGF-1 is most likely eliminated quite fast when administered in vivo due to the fact that it binds less to serum proteins such as IGFBPs
An example of an NO prodrug is O 2 -(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), devised by Keefer et al from the National Cancer Institute
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