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Routes reported in the literature include intravenous, subcutaneous, and intraperitoneal administration in animal models, with intravenous infusion common in the early human studies
This route can provide rapid absorption and may bypass some of the barriers associated with injectable administration
Once inside, it activates anorexigenic pathways
Retatrutide treatment is a next-generation therapy for weight management that targets GLP-1, GIP, and glucagon receptors to regulate appetite, improve blood sugar control, boost fat metabolism, and increase energy levels
Diabetes Obes Metab 14(Suppl 2):4149 Gabery S, Salinas CG, Paulsen SJ et al (2020) Semaglutide lowers body weight in rodents via distributed neural pathways
