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Christensen M, Vedtofte L, Holst JJ, Vilsbll T, Knop FK
If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below
GCGR/GLP-1R Dual Agonists: While retatrutide includes GCGR, other candidates like mazdutide are also exploring this dual target
Garcia Beltran et al
Janez A, Muzurovic E, Stoian AP, et al
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