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Int J Adv Res Biol Sci 6:113

However, most AI-assisted CRISPR platforms have been developed and validated using general genome-editing datasets rather than flavonoid-specific regulatory networks or combined stress systems, expanding these frameworks to incorporate stress-context-dependent regulatory information will therefore be essential for realizing their full potential in flavonoid metabolic engineering

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Interestingly, sustained activation of ROS can trigger various forms of programmed cell death, including apoptosis, ferroptosis, pyroptosis, necroptosis, oxeiptosis, NETosis, parthanatos, autophagy, necrosis and immunogenic cell death [22, 213, 214] (Fig

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