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Important context: While worsening heart failure events were meaningfully reduced, cardiovascular deaths were numerically higher in the tirzepatide group at 2.2% versus 1.4% in the placebo group
The STEP 2 trial [2] , which included participants with type 2 diabetes, showed slightly more modest but still substantial results, with 9.6% average weight loss compared to 3.4% with placebo
Dou L, Bertrand E, Cerini C, Faure V, Sampol J, Vanholder R, Berland Y, Brunet P (2004) The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair
class IIa A recommendation) already taking sodiumglucose cotransporter 2 inhibitors, without differentiating between HF phenotypes