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The barrier function is established by the lack of fenestrae in the vessels, the tight junctions connecting the endothelial cells, which prevent the paracellular route for external agents, and the low level of transcytotic vesicles (Rodrigues and Granger, 2015)
Int J Mol Sci 2023;24
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Consolidating into one device also reduces the number of pen changes required during a full titration study, which cuts the lot-number variables that need reconciling in dose logs
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