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Activation of gamma-globin expression by hypoxia-inducible factor 1alpha
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LSH can facilitate the expression of FADS2 and SCD1, which can increase the mRNA levels of ferroptosis-associated genes, such as SLC7A11 and GLUD1 , thus decreasing the intracellular levels of Fe 2+ and lipid ROS, finally suppressing ferroptosis in lung cancer [113]
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