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This means drug accumulation from early dosing could be more pronounced

Moreover, dapagliflozin markedly alleviates neuronal oxidative stress, tau phosphorylation and amyloid- production due to the ability to counteract neuronal apoptosis and upregulating glial cell-derived neurotrophic factor ( Alzheimers disease is also characterized by a reduced level of neuronal acetylcholine and the first line pharmacological treatment is based on the use of acetylcholinesterase inhibitors (Ferreira-Vieira et al., 2016)

Get this wrong, and every subsequent measurement will be inaccurate

Robert Kushner, who helped bring them to market, breaks down how they actually work, who benefits most, and why they're a long-term commitment rather than a quick fix