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Earlier biguanides such as phenformin and buformin showed greater potency but were withdrawn from the market due to a high incidence of lactic acidosis ( Pharmacokinetically, metformin is absorbed primarily in the small intestine, with a bioavailability of approximately 50%60% under fasting conditions (Table 1), depending on the formulation (immediate- vs
A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]
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