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Rethinking Hormone Replacement Therapy GLP-1 receptor agonists, as the preceding section established, address the metabolic consequences of estrogen withdrawal with considerable potency

[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance

Score 2: The mouse could not effectively use its hindlimbs or back into the cage by landing on head rather than paws

Studies suggest that the two peptides together can improve tissue regeneration, reduce scarring, and speed up recovery processes

Absence of evidence is not proof of failure