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Different types of antibodies facilitated crystallization of GLP-1R and GCGR into varied ECD orientations, whereas the structural differences in the TMD extracellular regions, including the stalk of helix I, is potentially due to sequence diversity between the two receptors

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After 6 weeks of choline-deficient HFD feeding, animals were dosed with vehicle (5% DMSO and 0.5% Kollidon-30 in 100 mM sodium phosphate buffer) or TLC-6665 (5 mg per kg (body weight)) once daily by oral gavage for the last 6 weeks