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This creates smaller individual GH pulses that may be more tolerable

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Oligodendrocyte death in pelizaeus-merzbacher disease is rescued by iron chelation

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Journal of Biological Chemistry, 266(7), 4029-4032

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Similar to the periplasm, the GSH:GSSG ratio in the ER is lower (3:1 to 1:1) compared to the cytosol (100:1), resulting in a more oxidizing environment (Hwang et al., 1992)

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