249,250 Relevant studies suggest that the expression of GLP-1R on -cells is crucial for GLP-1s regulation of somatostatin secretion and the overall inhibitory effect on glucagon
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[7] [9] Use is also contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as high doses of ascorbic acid may induce hemolysis in this population