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Phoenixin signals primarily through the G proteincoupled receptor GPR173, although aspects of its signaling biology remain incompletely defined

Slow titration is the most powerful tool you have

A total of 195 stroke survivors meeting the inclusion criteria (e.g., age 18 years, stable vital signs, no psychotropic medications or severe cognitive impairment) were enrolled

In retrospect, these adverse effects closely mirror those observed during early GLP-1 development, where rapid systemic exposure and high peak concentrations produced unacceptable gastrointestinal symptoms

Competing interests None of the authors have competing interest