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GLP2 versus GLP1 once weekly in patients with type 2 diabetes
GLP-1 medications without insurance can cost $800-$1,500 per month for brand-name versions, though compounded semaglutide options have brought costs down significantly
Patients with known peptide allergies or those who experienced adverse reactions to prior GLP-1 trials should not attempt therapy again without specialist evaluation
Cox HD et al
Glucagon receptor activation triggers energy-intensive processes: hepatic gluconeogenesis (the liver makes glucose from non-carbohydrate sources, requiring substantial ATP), fatty acid oxidation (mobilization machinery requires energy investment), and whole-body thermogenesis (every cell operates at higher energy expenditure)
